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Material:Drain-waste-vent pip - ABS Functional Units:1 foot of 3" ID pipe with 50 years service life
LCA Stage:Cradle to Site
Impact Category: Human Health Carcinogens Impact Units:life years
Sources:
Note: This list doesn't include 'Inactive' sources.
Source Stakeholder Submission Contributes Qualitative Information Contributes Quantitative Information
Exposure from occupational versus other sources. [Review] [107 refs] No No No
On cancer risk estimation of urban air pollution No No No
Human exposure to urban air pollution No No No
Mutagenicity studies on styrene and vinyl acetate. No No No
Mutagenicity of selected organic solvents. No No No
Application of integrated genetic monitoring: The optimal approach for detecting environmental carcinogens No No No
Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1,3-butadiene-exposed workers No No No
Styrene, styrene oxide, polystyrene, and beta -nitrostyrene/styrene carcinogenicity in rodents. No No No
Toxicity of the components of styrene polymers: Polystyrene, acrylonitrile-butadiene-styrene (ABS) and styrene-butadiene-rubber (SBR). Reactants and additives. No No No
Genotoxic effects of additives in synthetic elastomers with special consideration to the mechanism of action of thiurames and dithiocarbamates. No No No
Metabolism and mutagenicity of styrene and styrene oxide. No No No
Occupational hazards in production and processing of styrene polymers -- Epidemiologic findings. No No No
Change in semen quality and sperm chromatin structure following occupational styrene exposure No No No
Time/toxicity relationships in short-term static, dynamic, and plug-flow bioassays. No No No
Cancer risk assessment for the inhalation of 1,3-butadiene using physiologically based pharmacokinetic modeling. No No No
Mortality of styrene production, polymerization and processing workers at a site in northwest England. No No No
Increase of sister chromatid exchange and unscheduled synthesis of deoxyribonucleic acid by acrylonitrile in human lymphocytes in vitro. No No No
Degradation Products of Plastics: Polyethylene and Styrene-Containing Thermoplastics -- Analytical, Occupational and Toxicologic Aspects. No No No
Genetic toxicity of styrene and some of its derivatives. No No No
Prediction of Toxic Substances Emission for Occupational Exposure Assessment No No No
Styrene exposure and the liver. No No No
Acrylonitrile. No No No
Brain tumors and occupational risk factors.Aa review. No No No
Sampling and analysis of volatile organic compounds evolved during thermal processing of acrylonitrile butadiene styrene composite resins No Yes Yes
Nonisocyanate exposures in three flexible polyurethane manufacturing facilities. No No No
Biomonitoring of 1,3-butadiene and related compounds No No No
Concentrations and Sources of Volatile Organic Compounds in Urban Domestic and Public Microenvironments No No No
Acrylonitrile, acrylic and modacrylic fibres, and acrylonitrile-butadiene-styrene and styrene-acrylonitrile copolymers. [Review] [134 refs] No No No
Styrene: Evaluation of risks to health from environmental exposure in Canada No No No
Investigation of a Long-Term Sampling Period for Monitoring Volatile Organic Compounds in Ambient Air No No No
Concentrations and Sources of VOCs in Urban Domestic and Public Microenvironments No No No
Environmental exposure to 1,3-butadiene: A human health perspective No No No
Public health implications of 1990 air toxics concentrations across the United States No No No
An Assessment of Air Toxics in Minnesota No No No
A comprehensive evaluation of the potential health risks associated with occupational and environmental exposure to styrene.[erratum appears in J Toxicol Environ Health B Crit Rev 2002 Jul-Sep;5(3):335]. [Review] [223 refs] No No No
Mortality among workers at a butadiene facility. No No No
1,3-Butadiene: exposure estimation, hazard characterization, and exposure-response analysis. [Review] [133 refs] No No No
Multiple myeloma and engine exhausts, fresh wood, and creosote: A case-referent study. No No No
Vinyl chloride and acrylonitrile: activation mechanism and mutagenicity. No No No
Carcinogenicity of 1,3-butadiene. No No No
1,3-Butadiene. [Review] [348 refs] No No No
New aspects in the biomonitoring of occupational exposure to styrene. No Yes No
Acrylonitrile. [Review] [282 refs] No No No
Changes in the classification of carcinogenic chemicals in the work area. Section III of the German List of MAK and BAT Values. [Review] [36 refs] No No No
The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. [Review] [95 refs] No Yes No
1,3-butadiene: cancer, mutations, and adducts. Part V: Hemoglobin adducts as biomarkers of 1,3-butadiene exposure and metabolism. No No No
A method for estimating the magnitude and timing of excess cancer risks from less-than-lifetime exposures to contaminated well water No Yes No
1,3-butadiene: cancer, mutations, and adducts. Part III: In vivo mutation of the endogenous hprt genes of mice and rats by 1,3-butadiene and its metabolites. No No No
1,3-butadiene: cancer, mutations, and adducts. Part II: Roles of two metabolites of 1,3-butadiene in mediating its in vivo genotoxicity. No No No
The use of toxicologic data in mechanistic risk assessment: 1,3-butadiene as a case study. [Review] [34 refs] No No No
1,3-butadiene: cancer, mutations, and adducts. Part I: Carcinogenicity of 1,2,3,4-diepoxybutane. No No No
Some traditional herbal medicines, some mycotoxins, naphthalene and styrene. No No No
Emissions from processing thermoplastics No No Yes
Acrylonitrile inhalation in rats: I. Effect on intermediary metabolism. No No No
An analysis of the risk of B-lymphocyte malignancies in industrial cohorts. [Review] [84 refs] No No No
Assessment of risk from exposure to acrylonitrile: the general approach used by a consultant. No No No
A risk assessment for acrylonitrile in consumer products. No No No
An industrial perspective on a quantitative estimation of risk associated with low level exposures of humans, with acrylonitrile as a case study. No No No
Estimating Cancer Risk from Outdoor Concentrations of Hazardous Air Pollutants in 1990 No No No
Cancer occurrence among workers exposed to acrylonitrile. No No No
Review and meta-analysis of studies of acrylonitrile workers. No No No
Exposure estimation in four major epidemiologic studies in the acrylonitrile industry. [Review] [21 refs] No No No
Exposure assessment for a study of workers exposed to acrylonitrile. No No No
Mortality of industrial workers exposed to acrylonitrile. No No No
Human cancer risk and exposure to 1,3-butadiene--a tale of mice and men. [Review] [36 refs] No No No
Toxicology and carcinogenesis studies of acrylonitrile (CAS No. 107-13-1) in B6C3F1 mice (gavage studies). No No No
Acrylonitrile and human cancer--an overview. [Review] [5 refs] No No No
Mortality update of workers exposed to acrylonitrile in The Netherlands. No No No
Reconciling animal and human data in a cancer risk assessment of acrylonitrile.[comment]. No No No
Identification of 1-adenine DNA adducts in workers occupationally exposed to styrene. No No No
Monitoring of air toxics in the industrialized Texas Gulf Coast. No No No
Approaches to a health risk assessment of 1,3-butadiene as a toxic air contaminant. No No No
Toxicologic profile of acrylonitrile. [Review] [28 refs] No No No
Reevaluation of lung cancer risk in the acrylonitrile cohort study of the National Cancer Institute and the National Institute for Occupational Safety and Health.[comment]. No No No
How confident can we be that acrylonitrile is not a human carcinogen?[comment]. No No No
Gene deletion of glutathione S-transferase theta: correlation with induced genetic damage and potential role in endogenous mutagenesis. No No No
A review of health risks in acrylonitrile industry. No No No
Clinical toxicology of acrylonitrile. No No No
Living in a chemical world. Health impact of 1,3-butadiene carcinogenesis. No No No
Lymphohematopoietic cancers and butadiene and styrene exposure in synthetic rubber manufacture. No No No
Underestimating risk for three important human carcinogens: vinyl chloride, benzene, and butadiene. [Review] [19 refs] No No No
A summary of the NBS literature reviews on the chemical nature and toxicity of the pyrolysis and combustion products from seven plastics: Acrylonitrile--butadiene--styrenes (ABS), nylons, polyesters, polyethylenes, polystyrenes, poly(vinylchlorides) No No No
Review of occupational lung carcinogens. [Review] [167 refs] No No No
Polycyclic aromatic hydrocarbons in combustion residues from 1,3-butadiene No No No
Mortality among chemical plant workers exposed to acrylonitrile and other substances. No No No
Lymphatic and haematopoietic cancer mortality.[comment]. No No No
Inhalation exposure of rats and mice to 1,3-butadiene induces N6-adenine adducts of epoxybutene detected by 32P-postlabeling and HPLC. No No No
Long-term carcinogenicity bioassays on acrylonitrile administered by inhalation and by ingestion to Sprague-Dawley rats. No No No
Acrylonitrile as a carcinogen. Research needs for better risk assessment. No No No
Estimating dose response in chronic toxicity studies: 24-month administration of acrylonitrile in drinking water of Fischer 344 rats. No No No
Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity. [Review] [133 refs] No No No
Comparative developmental toxicities of aliphatic nitriles: in vivo and in vitro observations. No No No
A review of the developmental and reproductive toxicity of styrene. [Review] [99 refs] No No No
Assessment of 1,3-butadiene exposure in polymer production workers using HPRT mutations in lymphocytes as a biomarker. No No No
Urinary metabolites and haemoglobin adducts as biomarkers of exposure to 1,3-butadiene: a basis for 1,3-butadiene cancer risk assessment. No No No
Insights into the toxicokinetics and toxicodynamics of 1,3-butadiene. [Review] [36 refs] No No No
Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. [Review] [40 refs] No No No
Styrene respiratory tract toxicity and mouse lung tumors are mediated by CYP2F-generated metabolites. [Review] [63 refs] No No No
Dispersion of toxic combustion products from large fires. No No No
Mortality study of workers in 1,3-butadiene production units identified from a chemical workers cohort. No No No
Acrylonitrile: a reevaluation of the database to support an inhalation cancer risk assessment. No No No
A novel DNA adduct, originating from 1,2-epoxy-3,4-butanediol, is the major DNA adduct after exposure to [2,3-(14)C]-1,3-butadiene,[4-(14)C]-1,2-epoxy-3-butane. No No No
Dose-response implications of the University of Alabama study of lymphohematopoietic cancer among workers exposed to 1,3-butadiene and styrene in the synthetic rubber industry. No No No
A mortality, morbidity, and hematology study of petrochemical employees potentially exposed to 1,3-butadiene monomer. No No No
A cohort mortality study among workers at a 1,3 butadiene facility. No No No
Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industry. No No No
Markers for carcinogenicity among butadiene-polymer workers in China. No No No
Biomarkers for assessing occupational exposures to 1,3-butadiene. No No No
Point mutations of K-ras and H-ras genes in forestomach neoplasms from control B6C3F1 mice and following exposure to 1,3-butadiene, isoprene or chloroprene for up to 2-years. No No No
Mutagenicity at the Hprt locus in T cells of female mice following inhalation exposures to low levels of 1,3-butadiene. No No No
Mutational spectrum of 1,3-butadiene and metabolites 1,2-epoxybutene and 1,2,3,4-diepoxybutane to assess mutagenic mechanisms. No No No
Development of a preliminary physiologically based toxicokinetic (PBTK) model for 1,3-butadiene risk assessment. No No No
First-pass metabolism of 1,3-butadiene in once-through perfused livers of rats and mice. No No No
Cellular and molecular basis for species, sex and tissue differences in 1,3-butadiene metabolism. No No No
Occupational exposure to butadiene, isoprene and chloroprene. No No No
Overview of isoprene monomer and polyisoprene production processes. No No No
Significance of 1,3-butadiene to the US air toxics regulatory effort. No No No
Health risk assessment of 1,3-butadiene as a Priority Substance in Canada. [Review] [122 refs] No No No
DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation. No No No
Effects of alkyl nitriles on the gastrointestinal tract. [Review] [77 refs] No No No
Cancer of the prostate: an occupational disease?. No No No
Refinement and verification of the physiologically based dosimetry description for acrylonitrile in rats. No No No
Combustion products of 1,3-butadiene are cytotoxic and genotoxic to human bronchial epithelial cells. No No No
Butadiene--progress under the European Union Existing Substances Regulation. No No No
Genetic and reproductive toxicity of butadiene and isoprene. [Review] [95 refs] No No No
A review of the epidemiology of 1,3-butadiene and chloroprene. [Review] [30 refs] No No No
Comparative carcinogenicity of 1,3-butadiene, isoprene, and chloroprene in rats and mice. [Review] [28 refs] No No No
1,3-Butadiene, isoprene and chloroprene: reviews by the IARC monographs programme, outstanding issues, and research priorities in epidemiology. [Review] [37 refs] No No No
Tissue-specific genotoxic effects of acrylamide and acrylonitrile. No No No
Acrylonitrile interaction with testicular DNA in rats. No No No
Genotoxicity and cytotoxicity in male B6C3F1 mice following exposure to mixtures of 1,3-butadiene and styrene. No No No
DNA adducts of 1,3-butadiene in humans: relationships to exposure, GST genotypes, single-strand breaks, and cytogenetic end points. No No No
Human physiologic factors in respiratory uptake of 1,3-butadiene. No No No
Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks. No No No
Mutagenic spectrum of butadiene-derived N1-deoxyinosine adducts and N6,N6-deoxyadenosine intrastrand cross-links in mammalian cells. No No No
A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. No No No
Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage. No No No
Epidemiologic study of workers exposed to acrylonitrile. No No No
Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. No No No
Mortality patterns among employees exposed to acrylonitrile. No No No
Assessment of 1,3-butadiene mutagenicity in the bone marrow of B6C3F1 lacI transgenic mice (Big Blue): a review of mutational spectrum and lacI mutant frequency after a 5-day 625 ppm 1,3-butadiene exposure. No No No
Molecular analysis of hprt mutant lymphocytes from 1, 3-butadiene-exposed workers. No No No
Evaluation of 1,3-butadiene, isoprene and chloroprene health risks. No No No
NTP announces bioassay results. No No No
Problems with the solution. No No No
Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene. No No No
Intestinal toxicity of acrylonitrile: in vitro metabolism by intestinal cytochrome P450 2E1. No No No
Carcinogenicity of butadiene.[comment]. No No No
Activation of H-ras is prevalent in 1,3-butadiene-induced and spontaneously occurring murine Harderian gland tumors. No No No
Increased frequency of mutations at A:T base pairs in the bone marrow of B6C3F1 lacI transgenic mice exposed to 1,3-butadiene. No No No
Stereochemical aspects of 1,3-butadiene metabolism and toxicity in rat and mouse liver microsomes and freshly isolated rat hepatocytes. No No No
To what extent are biomonitoring data available in chemical risk assessment?. No No No
Mutagenic potential of guanine N2 adducts of butadiene mono- and diolepoxide.[erratum appears in Chem Res Toxicol 2000 May;13(5):430]. No No No
Biotransformation of styrene in mice. Stereochemical aspects. No No No
Mortality from tumours in workers in an acrylic fibre factory. No No No
Teratogenicity of acrylonitrile given to rats by gavage or by inhalation. No No No
Comparative toxicokinetics of 2,3-14C-and 1-14C-acrylonitrile in the rat. No No No
Epidemiology of brain tumours in man and their relationship with chemical agents. No No No
Minimal effects of acrylonitrile on pulmonary and hepatic cell injury enzymes in rats with induced cytochrome P450. No No No
Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. No No No
Examination of low-incidence brain tumor responses in F344 rats following chemical exposures in National Toxicology Program carcinogenicity studies. No No No
The effect of acrylonitrile on gap junctional intercellular communication in rat astrocytes. No No No
Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years. No No No
Epidemiologic study of workers exposed to acrylonitrile: An update. No No No
Cancer incidence of workers exposed to dimethylformamide and/or acrylonitrile. No No No
In-vitro testicular bioactivation of acrylonitrile. No No No
Detection of styrene and styrene oxide-induced DNA damage in various organs of mice using the comet assay. No No No
New models for assessing carcinogenesis: an ongoing process. [Review] [51 refs] No No No
A toxicokinetic model for styrene and its metabolite styrene-7,8-oxide in mouse, rat and human with special emphasis on the lung.[comment]. No No No
Nasal Carcinoma in Woodworkers: A Review. No No No
Possible functional immunotoxicity of acrylonitrile (VCN). No No No
The chromosome-based challenge assay using fluorescence in situ hybridization: a possible test for increased cancer susceptibility. No No No
Micronuclei and gene mutations in transgenic big Blue((R)) mouse and rat fibroblasts after exposure to the epoxide metabolites of 1, 3-butadiene. No No No
Comparative chronic toxicity and carcinogenicity of acrylonitrile by drinking water and oral intubation to Spartan Sprague-Dawley rats. No No No
Percutaneous absorption and chemical carcinogenesis. No No No
Consequences of acrylonitrile metabolism in rat hepatocytes: effects on lipid peroxidation and viability of the cells. No No No
Synthesis report of the step project detection of germ cell mutagens. [Review] [76 refs] No No No
Reactive chemicals and cancer. [Review] [129 refs] No No No
Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers. No No No
The in vivo mutagenicity and mutational spectrum at the lacI transgene recovered from the spleens of B6C3F1 lacI transgenic mice following a 4-week inhalation exposure to 1,3-butadiene. No No No
Induction of oxidative stress in rat brain by acrylonitrile (ACN). No No No
Chronic toxicity/oncogenicity study of styrene in CD rats by inhalation exposure for 104 weeks. No No No
Inhibition of cytochrome P450 2E1 decreases, but does not eliminate, genotoxicity mediated by 1,3-butadiene. No No No
Quantification of DNA adducts formed in liver, lungs, and isolated lung cells of rats and mice exposed to (14)C-styrene by nose-only inhalation. No No No
Association between genetic polymorphisms and biomarkers in styrene-exposed workers. No No No
Three-generation reproduction study of rats receiving acrylonitrile in drinking water. No No No
Two-year toxicity and oncogenicity study with acrylonitrile incorporated in the drinking water of rats. No No No
Mechanisms for the induction of oxidative stress in Syrian hamster embryo cells by acrylonitrile. No No No
DNA adducts of styrene-7,8-oxide in target and non-target organs for tumor induction in rat and mouse after repeated inhalation exposure to styrene. No No No
Genotoxicity--threshold or not? Introduction of cases of industrial chemicals. [Review] [55 refs] No No No
Mutagenicity of 1,3-butadiene inhalation in somatic and germinal cells of mice. No No No
Levels of ras oncoproteins in human plasma from 1,3-butadiene-exposed workers and controls. No No No
Mutagenicity of 1,3-butadiene at the Hprt locus of T-lymphocytes following inhalation exposures of female mice and rats. No No No
Congenital abnormalities and indicators of germinal mutations in the vicinity of an acrylonitrile producing factory. No No No
An evaluation of styrene genotoxicity using several biomarkers in a 3-year follow-up study of hand-lamination workers. No No No
Comparison of the mutations at Hprt exon 3 of T-lymphocytes from B6C3F1 mice and F344 rats exposed by inhalation to 1,3-butadiene or the racemic mixture of 1,2:3,4-diepoxybutane. No No No
The enemy at the gates? DNA adducts as biomarkers of exposure to exogenous and endogenous genotoxic agents. [Review] [38 refs] No No No
Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice. No No No
A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study. No No No
Mechanistic and toxicokinetic data reducing uncertainty in risk assessment. [Review] [37 refs] No No No
Role of glutathione in liver-mediated mutagenicity of acrylonitrile. No No No
Metabolism and mutagenicity of acrylonitrile: an in vivo study. No No No
Induction of micronuclei in peripheral blood and bone marrow erythrocytes of rats and mice exposed to 1,3-butadiene by inhalation. No No No
1,3-Butadiene working group report. [Review] [41 refs] No No No
A comparison of male-mediated effects in rats and mice exposed to 1,3-butadiene. No No No
Genetic effects of 1,3-butadiene on the mouse testis. No No No
Genetic analysis of Raf1, Mdm2, c-Myc, Cdc25a and Cdc25b proto-oncogenes in 2',3'-dideoxycytidine- and 1,3-butadiene-induced lymphomas in B6C3F1 mice. No No No
Heritable translocations induced by inhalation exposure of male mice to 1,3-butadiene. No No No
Comparison of cytogenetic effects of 3,4-epoxy-1-butene and 1,2:3, 4-diepoxybutane in mouse, rat and human lymphocytes following in vitro G0 exposures. No No No
A review of the genetic and related effects of 1,3-butadiene in rodents and humans. [Review] [173 refs] No No No
Mutations induced by 1,3-butadiene metabolites, butadiene diolepoxide, and 1,2,3,4-diepoxybutane at the Hprt locus in CHO-K1 cells. No No No
Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air. No No No
Acrylonitrile-induced sister-chromatid exchanges and DNA single-strand breaks in adult human bronchial epithelial cells. No No No
Aneuploidy in Drosophila, IV. Inhalation studies on the induction of aneuploidy by nitriles. No No No
The use of transgenic mice for studying mutagenicity induced by 1,3-butadiene. No No No
Sister-chromatid exchanges, glutathione S-transferase theta deletion and cytogenetic sensitivity to diepoxybutane in lymphocytes from butadiene monomer production workers. No No No
EC/US workshop report: assessment of genetic risks associated with exposure to ethylene oxide, acrylamide, 1,3-butadiene and cyclophosphamide. No No No
Molecular and genetic toxicology of 1,3-butadiene. [Review] [51 refs] No No No
Chromosome aberrations and response to gamma-ray challenge in lymphocytes of workers exposed to 1,3-butadiene. No No No
Role of glutathione modulation in acrylonitrile-induced gastric DNA damage in rats. No No No
Mutagenicity, carcinogenicity, and teratogenicity of acrylonitrile. [Review] [188 refs] No No No
New aspects in genotoxic risk assessment of styrene exposure--a working hypothesis. [Review] [41 refs] No No No
Spectrum of styrene-induced DNA adducts: the relationship to other biomarkers and prospects in human biomonitoring. [Review] [84 refs] No No No
Genotoxic properties of acrylonitrile. No No No
Carcinogenicity and other health effects of acrylonitrile with reference to occupational exposure limit. [Review] [106 refs] No No No
Interest of genotyping and phenotyping of drug-metabolizing enzymes for the interpretation of biological monitoring of exposure to styrene. No No No
The role of epoxides in the metabolic activation of styrene to mutagens. No No No
Biotransformation of styrene to mutagenic 1-vinylbenzene 3,4-oxide by hepatic microsomes. No No No
Cancer risk assessment for the inhalation of 1,3-butadiene. No No No
DNA damage in lung cells in vivo and in vitro by 1,3-butadiene and nitrogen dioxide and their photochemical reaction products. No No No
Butadiene and isoprene: future studies and implications. No No No
Inhalation toxicity and carcinogenicity of isoprene in rats and mice: comparisons with 1,3-butadiene. [Review] [22 refs] No No No
Risk assessment of butadiene for the Existing Substances Regulation (ESR) in the European Union. No No No
Review of risk assessments on 1,3-butadiene (1985-1991). [Review] [17 refs] No No No
Mortality update of butadiene production workers. No No No
Mortality study of workers employed in 1,3-butadiene production units identified from a large chemical workers cohort. No No No
Butadiene epidemiology: a summary of results and outstanding issues. [Review] [30 refs] No No No
Mutagenicity and mutational spectra of 1,3-butadiene in the bone marrow of B6C3F1 lacI transgenic mice. No No No
Monitoring of exposure to acrylonitrile by determination of N-(2-cyanoethyl)valine at the N-terminal position of haemoglobin. No No No
Comparison of the disposition of butadiene epoxides in Sprague-Dawley rats and B6C3F1 mice following a single and repeated exposures to 1,3-butadiene via inhalation. No No No
Molecular modelling of CYP2E1 enzymes from rat, mouse and man: an explanation for species differences in butadiene metabolism and potential carcinogenicity, and rationalization of CYP2E substrate specificity. No No No
Evaluation of genotoxic effects in a group of workers exposed to low levels of styrene. No No No
Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes. No No No
Monograph on human exposure to chemicals in the workplace: Styrene. No No No
In vitro transformation of C3H/10T1/2 and NIH/3T3 cells by acrylonitrile and acrylamide. No No No
Monitoring exposure to acrylonitrile using adducts with N-terminal valine in hemoglobin. No Yes No
Evaluation of Butadiene and Isoprene Health Risks. Proceedings of the international symposium. Blaine, Washington, June 27-29, 1995. No No No
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice. No No No
A physiological toxicokinetic model for 1,3-butadiene in rodents and man: blood concentrations of 1,3-butadiene, its metabolically formed epoxides, and of haemoglobin adducts--relevance of glutathione depletion. No No No
Using PBPK modeling and comprehensive realism methodology for the quantitative cancer risk assessment of butadiene. No No No
Risk assessment of butadiene in ambient air; the approach used in the UK. No No No
Future research needs for non-cancer and cancer effects among populations exposed to 1,3-butadiene. [Review] [43 refs] No No No
Male-mediated F1 effects in mice exposed to 1,3-butadiene. No No No
hprt mutation frequency among workers exposed to 1,3-butadiene in China. No No No
Biological monitoring for mutagenic effects of occupational exposure to butadiene. No No No
Assessment of exposure to butadiene in the process industry. No No No
Metabolism of butadiene by mice, rats, and humans: a comparison of physiologically based toxicokinetic model predictions and experimental data. No No No
Biochemistry of 1,3-butadiene metabolism and its relevance to 1,3-butadiene-induced carcinogenicity. No No No
Induction of oxidative stress and oxidative damage in rat glial cells by acrylonitrile. No No No
Benzene emissions from ethylbenzene/styrene plants - background information for proposal to withdraw proposed standards. No No No
Epidemiological and mechanistic data suggest that 1,3-butadiene will not be carcinogenic to humans at exposures likely to be encountered in the environment or workplace. [Review] [45 refs] No No No
Mechanistic data indicate that 1,3-butadiene is a human carcinogen. [Review] [62 refs] No No No
Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene. No No No
PBPK model for butadiene metabolism to epoxides: quantitative species differences in metabolism. No No No
Effects of the structure of a toxicokinetic model of butadiene inhalation exposure on computed production of carcinogenic intermediates. No No No
Physiologically based pharmacokinetic modeling of 1,3-butadiene, 1,2-epoxy-3-butene, and 1,2:3,4-diepoxybutane toxicokinetics in mice and rats. No No No
Dithiocarbamates as potential confounders in butadiene epidemiology. No No No
Acrylonitrile-induced morphological transformation in Syrian hamster embryo cells. No No No
Human sensitivity to 1,3-butadiene: role of microsomal epoxide hydrolase polymorphisms. No No No
The role of cytochromes P-450 in styrene induced pulmonary toxicity and carcinogenicity. No No No
Cancer risk estimation of genotoxic chemicals based on target dose and a multiplicative model. No No No
CNS tumors and exposure to acrylonitrile: inconsistency between experimental and epidemiology studies. No No No
Air toxics and health risks in California: the public health implications of outdoor concentrations. No No No
Genotoxic markers among butadiene polymer workers in China. No No No
Improving cancer dose-response characterization by using physiologically based pharmacokinetic modeling: an analysis of pooled data for acrylonitrile-induced brain tumors to assess cancer potency in the rat. No No No
Exaggerated carcinogenicity of chemicals.[comment]. No No No
Spermatogenesis and mutagenicity of environmental hazards: extrapolation of genetic risk from mouse to man. [Review] [26 refs] No No No
Comparison of the dominant lethal effects of acrylonitrile and acrylamide in male Fischer 344 rats. No No No
Assessment of environmental and occupational exposures to butadiene as a model for risk estimation of petrochemical emissions. No No No
Mutagenicity of urine from rats and mice treated with acrylonitrile. No No No
Analysis of cancer risks in 19 U.S. cities from air toxics monitoring data and comparison with risks based on dispersion modeling of emissions data. No No No
Ambient Water Quality Criteria for the Protection of Human Health: Acrylonitrile No No No
TRACI: The Tool for the Reduction and Assessment of Chemical and Other Environmental Impacts No No No
Intake fraction for multimedia pollutants: a tool for life cycle analysis and comparative risk assessment No No Yes
ETH-ESU 96 Unit processes database. In: Simapro6 No No Yes
Franklin database. In: Simapro6 No No Yes
Compilation of cancer potency factors and acceptable daily intake values No No Yes
Human toxicity potentials for life cycle analysis and toxics release inventory risk screening. No Yes No
Perspectives in Life Cycle Impact Assessment; A structured approach to combine models of the technosphere, ecosphere , and valuesphere No No Yes
IDEMAT. In: Simapro6 No No No
Data Archive library. In: SimaPro6 No No No
Industry Data library. In: SimaPro6 No Yes No
SimaPro 6 No No Yes
National-Scale Air Toxics Assessment for 1996: Appendix H Estimating Carcinogenic Potency for Mixtures of Polycyclic Organic Matter (POM) for the 1996 National-Scale Assessment. No No Yes
Locating and estimating air emissions from sources of polycyclic organic matter No No Yes
Toxic release inventory public data release No Yes No
Ecoprofiles of the European plastics industry, report 13 , Co-polymers of Acrylonitrile-Butadiene- Styrene (ABS) and Styrene-Acrylonitrile (SAN), October 1997. No No Yes